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Pacijente treba pažljivo pratiti u cilju prepoznavanja znakova i simptoma respiratorne depresije i sedacije. U ovom pogledu se preporučuje informisanje pacijenata i njihovih staratelja (kada je to primenljivo) o značajnosti prepoznavanja ovih simptoma (videti odeljak four.five).

Zbog sličnosti oksidativnih procesa, diazepam kompetitivno inhibira metabolizam ketamina. Premedikacija sa diazepamom dovodi do produženog poluvremena eliminacije ketamina, što za rezultat ima njegovo pojačano dejstvo. Pojačana sedacija.

Prijavljeno je da natrijum-valproat istiskuje diazepam sa mesta vezivanja za proteine plazme (povećana koncentracija u serumu: povećan rizik od pospanosti).

Should you take the put together pill or the progestogen-only tablet and tramadol tends to make you vomit or have severe diarrhoea for much more than 24 hours, it may well not protect you from pregnancy. Examine the pill packet to see what to do.

The existence of other clinical complications might affect the use of this medicine. You should definitely notify your health practitioner For those who have another healthcare complications, Primarily:

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Hipoalbuminemija može predisponirati pacijenta ka povećanoj incidenci sedativnih neželjenih dejstava. Potreban je izuzetan oprez pri propisivanju diazepama pacijentima sa poremećajima ličnosti.

Study the Medication Guidebook provided by your pharmacist Before you begin getting acetaminophen/codeine and each time you will get a refill. For those who have any concerns, question your medical professional or pharmacist.

Pri primeni terapijskih doza leka može se javiti anterogradna amnezija, rizik je povećan pri primeni većih doza. Efekat amnezije može biti udružen sa neprikladnim read more ponašanjem (videti odeljak four.four).

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Diazepam se ne sme koristiti kao monoterapija u terapiji depresije i anksioznosti udružene sa depresijom, jer kod ove grupe pacijenata može uzrokovati pojavu suicida.

Tell your health practitioner straight away if you're thinking that you're pregnant or if you plan to be pregnant whilst applying this medication.

This is not a get more info whole listing of possible Uncomfortable side effects. If you recognize other effects not detailed earlier mentioned, Get hold of your physician or pharmacist.

Tramadol and acetaminophen mix is applied To ease acute suffering critical plenty of to have to have an opioid remedy and when other ache medicines did not work perfectly more than enough or can't be tolerated.